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The 5:2 Lab

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KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation

full paper available here

http://www.cell.com/retrieve/pii/S0092867413012762

It's not going to let most of us off the hook - we've just eaten / drunken too much - but it might explain things for some.

And, as the researchers say, there's maybe hope for "a novel therapeutic strategy for obesity and type 2 diabetes".

@Carorees might be up for dissecting it :)
I wasn't expecting that. It seems that every signaling pathway I am interested in turns out to be linked to obesity.
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