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The 5:2 Lab

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If I'm not mistaken, his lab is the one that did the biggest loser study.

I found this study a bit difficult to follow, but the implications for increased hunger after weight loss are kind of shocking. Links to original paper and a write up by Guyenet below: ... 21653/full ... ve-to-eat/

This meta analysis compares the impact of carbs vs. fat on energy expenditure ... y-fatness/

05 May 2017, 03:22
This is the same thing that Dr. Amanda Sainsbury-Salis talked about in her books. She said the body is programmed with a "set weight" and that when you go significantly below the set weight, your body makes you hungrier, slows down your metabolism and makes you not want to move until you gain the weight back.

She does, however, say you can (1) power thought this, not by eating very little, but by eating a lot of very, very healthy food and (2) you can over time change your set weight, but it's not easy.

This is part of the reason I've not minded the slow course my weight loss has taken. I've had a couple of set points I noticed. I was 272 for a very long time and couldn't seem to budge from that -- either higher or lower. Then I rather settled at 241 for a while - well over a year. Then I settled at about 230, again for a bit over a year. I got down to 197 in August, then after a very stressful fall, found myself at 213, and holding steady at that for a few months. I've been fighting that right now, currently 203.5

It is going to take some work to make sure I dont' go back up, but the longer you stay at a weight, the more your body starts to accept it as a new set point.

05 May 2017, 09:39
Thanks again @MaryAnn

Stephan Guyenet's summaries are very useful, and it was interesting to read the comments below them.

07 May 2017, 14:34
Fascinating reports, thank you for this.

It explains pretty much what has happened to me over the last 4 years, having never dieted before and losing a stone and a half in the first 6 months of 5:2 fasting. The long slow increase back to where I started is disheartening but not my fault it seems, and I've learned a lot about nutrition on the way.

Certainly there are many vested interests arguing their corner out there on the food market place, differing methodology/morality all shouting that theirs alone is right, but we seem to have proved here that each individual will react at variance to another, no one ideal, and gender plays a bigger part than has been researched.

Gender, age, health are our base starting point, add in BMR as some sort of gauge, and then eat a colourful variety of real foods when hungry, preferably within a daily 8 hour window, and preferably sleeping 8 hours a night.

If you can feel realistically positive about yourself, your aims and relationships, then all shall be well.
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