"Impaired capacity to lose visceral adipose tissue during weight reduction in obese postmenopausal women with the Trp64Arg beta3-adrenoceptor gene variant."
http://diabetes.diabetesjournals.org/co ... 1709.short
I would have to get my 3rd yr BSc biology student daughter to explain the genetics, but this study appears to show that "carriers of the Trp64Arg variant had smaller reductions in intra-abdominal fat compared with normal homozygotes" so while both normal and "carriers" lost at least 10 kg of fat over a year (1200 kcal diet) the carriers lost a lot less intra-abdominal fat (although they did have less to start with, which may be part of the same influence).
Activity levels were similar - "The program did not induce significant changes in
leisure time physical activity (295 ± 188 vs. 247 ± 170 kcal/day
before and after weight loss, respectively; P= 0.36)"
The normal group had a larger reduction in total/HDL cholesterol ratio, having started at a higher level.
http://diabetes.diabetesjournals.org/co ... 1709.short
I would have to get my 3rd yr BSc biology student daughter to explain the genetics, but this study appears to show that "carriers of the Trp64Arg variant had smaller reductions in intra-abdominal fat compared with normal homozygotes" so while both normal and "carriers" lost at least 10 kg of fat over a year (1200 kcal diet) the carriers lost a lot less intra-abdominal fat (although they did have less to start with, which may be part of the same influence).
Activity levels were similar - "The program did not induce significant changes in
leisure time physical activity (295 ± 188 vs. 247 ± 170 kcal/day
before and after weight loss, respectively; P= 0.36)"
The normal group had a larger reduction in total/HDL cholesterol ratio, having started at a higher level.
