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The 5:2 Lab

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http://www.sott.net/article/242516-Hear ... rt-disease

My very clever friend posted this on Facebook. I found it very easy to read and it explains things well. I would be interested in critical feed back from our clever people here...
thanks
janeg
Thanks for sharing this. I'm curious to hear what our chief geeks have to say about this :)
As you say an interesting, easy to read article. I too would be interested in others' views on it.
GEEK: The most efficient way devised for standing on the shoulders of giants while avoiding being crushed by their toes of experience. - Me
Well @janeg I like to look up the authenticity if these blokes.

http://www.quackwatch.org/11Ind/lundell.html

So whilst I do believe inflammation is definitely the bad guy in heart disease abd dementia, I'm not sure that we will all be scrubbing our arteries with a wire brush every time we eat a piece if bread or slice of cake. I also wonder about the acid vs alkaline body that was such a popular topic when I was last in US. I experimented and found lemon juice in water reduced acidity levels dramatically. I wonder if this would reduce inflammation?
Well @janeg I like to look up the authenticity of these blokes.

http://www.quackwatch.org/11Ind/lundell.html

So whilst I do believe inflammation is definitely the bad guy in heart disease and dementia, I'm not sure that we will all be scrubbing our arteries with a wire brush every time we eat a piece of bread or slice of cake. I also wonder about the acid vs alkaline body that was such a popular topic when I was last in US. I experimented and found lemon juice in water reduced acidity levels dramatically. I wonder if this would reduce inflammation?
Thanks @Janeg interesting comments follow the article too with recommending reading. Like others I'm always interested to learn. The article is 3 years old, wonder what Lundell's view is today, despite being forcefully retired by the sounds of it.
Very interesting.
No one mentions that genetic makeup is diffferent in everyone and how this seems to affect individuals differently.
tenshi
I think that the link between cardiovascular disease and inflammation is fairly well established, but the link between carbs/sugar and inflammation is less well accepted. However, I found a few papers supporting the possibility that raised blood sugar increases inflammation, at least in people with type 2 diabetes:
http://www.ncbi.nlm.nih.gov/pubmed/25456098
http://www.ncbi.nlm.nih.gov/pubmed/23686079
http://www.ncbi.nlm.nih.gov/pubmed/12117736

Another link between obesity and inflammation and heart disease is via the effects of hormones secreted by adipose tissue on inflammation, which may create an indirect link between eating a high carb diet and inflammation (carbs being turned to fat and hence stimulating adipose tissue to release hormones such as leptin). http://www.ncbi.nlm.nih.gov/pubmed/24936256

This study in mice suggests that it could be a combination of the two: http://www.ncbi.nlm.nih.gov/pubmed/24438079 they found that mice fed a high fat diet (which in the mouse world actually means high fat plus fairly high carb) developed significant diet-induced obesity, adipose tissue inflammation, insulin resistance, and impaired glucose tolerance compared to lean mice but that those fed high fat plus high sugar developed significantly higher inflammation in parallel with significantly increased atherosclerosis.

Fasting is known to be anti-inflammatory which might be due to the drop in blood glucose and/or its effects on leptin secretion.

So, yes, despite him being discredited at the time, it looks like he was right after all.
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