The FastDay Forum

The 5:2 Lab

7 posts Page 1 of 1
I came across this paper investigating the effect of a high vs low GL (glycaemic load) diet on IGF-1 levels.

The researchers used a crossover design (i.e., the same subjects experienced both diets) in 84 overweight-obese and normal weight healthy individuals using two 28-day weight-maintaining high- and low-GL diets (both were 15% energy from protein, 30% energy from fat and 55% energy from carbohydrate, but differed in GL, one being ≥ 250 and the other ≤ 125). They measured both fasting and post-prandial concentrations of insulin, glucose, IGF-1 and IGFBP-3.

Low-GL diet resulted in a 43% lower glucose and 27% lower insulin response after a meal, and while fasting serum glucose concentrations were similar between diet treatments in the lean group, this was not the case in the overweight/obese group: mean fasting glucose was 0.12 mmol/L higher following the low- compared to the high-GL diet. The low-GL diet led to 4% lower fasting concentrations of IGF-1 (10.6 ng/mL, p = 0.04) and a 4% lower ratio of IGF-1/IGFBP-3 (0.24, p = 0.01) compared to the high-GL diet.

This study, therefore, suggests that lowering refined carbs can not only improve glucose metabolism but also have some effect on IGF-1 so helping to reduce cancer risks.
Really interesting article - thank you Caroline. I think you're right - it's the way to go. I still find it slightly confusing trying to work out what carbs are ok ones though - is rye bread ok, for example? I've read conflicting things. Perhaps I should stop reading and just stop eating white things.
Thanks for posting this Caroline. More food for thought. Start slowly loversghost. I have been sugar free and low GI now for 4 weeks and the first few weeks were about cutting refined carbs before moving to the stage where I have now more or less given up all grains but do have a weekend 'treat' of a slice of soughdough toast if I feel like it. The best thing about this is that my cravings have all but disappeared and it makes fast days much easier.
Thanks rawkaren - will take your advice but I have found my cravings for carbs have been much easier to control since starting this - I tried eating in a GL fashion before and really struggled with the desire for refined carbs so wasn't very successful - this WOE has really helped with those cravings.
Thanks for posting this. I'm not diagnosed with diabetes, but think that I have suffered from insulin resistane/metabolic syndrome. Since combining intermittent fasting with a low carbohydrate diet my blood glucose levels have become more stable. If I relax a little the levels shoot up. So I'm probably in this for the long term.
Hi @Bracken

Did you see this that I just posted about low carb diets in diabetes? topic13054.html
Dear Caroline, yes I did. I thought that I had posted my reply on there!
7 posts Page 1 of 1
Similar Topics

Who is online

Users browsing this forum: No registered users and 4 guests

START THE 5:2 DIET WITH HELP FROM FASTDAY

Be healthier. Lose weight. Eat the foods you love, most of the time.

Learn about the 5:2 diet

LEARN ABOUT FASTING
We've got loads of info about intermittent fasting, written in a way which is easy to understand. Whether you're wondering about side effects or why the scales aren't budging, we've got all you need to know.

Your intermittent fasting questions answered ASK QUESTIONS & GET SUPPORT
Come along to the FastDay Forum, we're a friendly bunch and happy to answer your fasting questions and offer support. Why not join in one of our regular challenges to help you towards your goal weight?

Use our free 5:2 diet tracker FREE 5:2 DIET PROGRESS TRACKER & BLOG
Tracking your diet progress is great for staying motivated. Chart your measurements and keep tabs on your daily calorie needs. You can even create a free blog to journal your 5:2 experience!

cron