I found this (not too recent but still interesting) study looking at how losing weight, maintaining a reduced weight and gaining weight affects insulin sensitivity, glucose metabolism and mechanisms that affect energy expenditure, namely thyroid function and catecholamine release.
Some interesting excerpts:
Discuss!
Some interesting excerpts:
Serum T3 decreased significantly and rT3 increased significantly in never-obese subjects (n = 19), but not in the smaller group of obese subjects (n = 6) after a 10% weight loss. However, in the larger group of obese subjects (n = 10) examined at Wtinitial and after a 10% weight loss, serum T3 decreased significantly and rT3 increased significantly during maintenance of a reduced body weight.
Maintenance of a reduced body weight was associated with significant decreases in urinary excretion of norepinephrine in obese and never-obese subjects and in dopamine in never-obese subjects only.
This analysis [linear regression] suggests that whatever effect the changes in circulating concentrations of T3 exert on changes in energy expenditure must be due to changes in sympathetic nervous system tone.
No significant effects of weight loss on serum glucose or insulin concentrations were noted in either obese or never-obese subjects at Wt–10%; however, insulin excursions were significantly lower in obese subjects studied at Wt–20% than in the same subjects studied at Wtinitial
At all weight plateaus, plasma leptin concentrations normalized to fat mass were significantly higher in women than in men. Plasma leptin concentrations normalized to fat mass decreased significantly at Wt–10% in women but not in men. Plasma leptin concentrations were significantly correlated with fasting plasma insulin concentrations.
Discuss!
