MaryAnn wrote: I am curious about whether there is any scientific evidence for refeeding to get over a plateau or generally boost metabolism. I've been reading around a lot about metabolic changes (in TDEE, appetite hormones, etc.) that occur upon weight loss--the things that lead to plateaus and/or difficulty with maintenance after reaching goal. Everything I've seen suggests that this will go on for a long time after losing 10% of body weight--even after 6 months, hormone levels don't recover to pre-weight loss levels, for example. Can any one point me to a study that shows referring works? I've tried to look through Amanda Sainsbury's stuff, but haven't found anything yet.
As you know, the concept of feasting/fasting has really only just begun to be investigated scientifically. However, there seems to be increasing evidence that periodic depletion of glycogen stores is beneficial for health whether this depletion is achieved through exercise and/or fasting. Here is an interesting paper that investigated the effect of carbohydrate overfeeding on metabolic rate in the context of previously depleted glycogen stores (by exercise in this case).
http://www.ncbi.nlm.nih.gov/pubmed/2246961The authors conclusions are:
Carbohydrate overfeeding did not affect RMR, but increased DIT [diet induced thermogenesis] significantly, on average by 39%. Glycogen-depleting exercise the day before increased RMR significantly by, on average, 9% and increased DIT (P = .08), on average, by 23%. The impact of exercise on RMR was less when carbohydrate overfeeding was administered, but there was no significant interaction effect of carbohydrate overfeeding and exercise on RMR or DIT. It is concluded that both prior glycogen-depleting exercise and an antecedent diet high in carbohydrates may influence RMR or DIT.
So this paper finds that a period of overfeeding increases energy use via diet induced thermogenesis, while glycogen depletion through exercise increased resting metabolic rate. Perhaps understandably, combining glycogen depletion with carbohydrate over-feeding had less effect on metabolic rate.
I wonder whether the reduction in appetite that occurs with 5:2 or other fasting methods results in a daily calorie deficit and so the aforementioned slowing in metabolic rate (adaptive thermogenesis) which may perhaps be reversed temporarily by a re-feed.
If you look at the leangains website, you'll see that Martin Berkhan is keen on the idea of 16:8 combined with exercise but with periodic scheduled re-feeds. I haven't delved too far into his website but there may be some links to research there.