Varady has indeed been studying ADF for a long time but the individual studies reported by her in the scientific literature have not been long term studies. The participants only followed ADF for 2-3 months. However, they're the best studies to date. My current area of interest is the number of people who have been using IF in some form whether 5:2 or 4:3 maybe combined with an eating window on non-fast days who have run into problems with weight loss stalling. There are many factors involved in such stalls, but I think that too much fasting can cause cortisol levels to increase worsening insulin sensitivity and slowing weightloss. Fasting is mildly stressful on the body and so if you have other stresses in your life, you can over do things. So, my comment about Varadys published studies being relatively short term was aimed at pointing out we don't yet know what effects following 5:2 or ADF for years might have. There is, in fact, one study of ADF in young lean women that showed temporary worsening of insulin sensitivity (resolved on stopping fasting) but that study involved no calories on the fast days. Hopefully, the 500/600 cal meal used in Varady's studies is enough to prevent the cortisol rise. I understand that she has done some longer studies but they don't seem to have been published yet.
I think 4:3 or ADF for a few months to lose weight is fine but I'd be wary of getting to a situation where I needed to do it for ever to keep the weight off. Your plan to drop back to 5:2 or 6:1 is sensible I think.
I think 4:3 or ADF for a few months to lose weight is fine but I'd be wary of getting to a situation where I needed to do it for ever to keep the weight off. Your plan to drop back to 5:2 or 6:1 is sensible I think.